Breast cancer is the most common cancer in women, and incidence rates are rising, it is thought in part, due to increasing levels of obesity. Endocrine therapy (ET) remains the cornerstone of systemic therapy for early and advanced oestrogen receptor-positive (ER + ) breast cancer, but despite treatment advances, it is becoming more evident that obesity and insulin resistance are associated with worse outcomes. Here, we describe the current understanding of the relationship between both obesity and diabetes and the prevalence and outcomes for ER+ breast cancer. We also discuss the mechanisms associated with resistance to ET and the relationship to treatment toxicity.
Journal article
2024-12-01T00:00:00+00:00
131
1724 - 1736
12
Humans, Insulin Resistance, Breast Neoplasms, Obesity, Female, Receptors, Estrogen, Drug Resistance, Neoplasm, Antineoplastic Agents, Hormonal